Cardiovascular outcomes with canagliflozin – is it on the CANVAS?
نویسندگان
چکیده
منابع مشابه
Rationale, design and baseline characteristics of the CANagliflozin cardioVascular Assessment Study–Renal (CANVAS‐R): A randomized, placebo‐controlled trial
AIMS The primary aim of the CANagliflozin cardioVascular Assessment Study-Renal (CANVAS-R) is to determine whether the favourable effects of inhibition of the sodium glucose co-transporter 2 (SGLT2) on blood glucose, blood pressure and body weight are accompanied by protection against adverse renal outcomes. MATERIALS AND METHODS CANVAS-R is a prospective, randomized, double-blind, placebo-co...
متن کاملCardiovascular outcomes associated with canagliflozin versus other non-gliflozin antidiabetic drugs: population based cohort study
OBJECTIVE To evaluate the cardiovascular safety of canagliflozin, a sodium-glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus, in direct comparisons with DPP-4 inhibitors (DPP-4i), GLP-1 receptor agonists (GLP-1RA), or sulfonylureas, as used in routine practice. DESIGN Population based retrospective cohort study. SETTING Nationwide sample of patients with type 2...
متن کاملSGLT2 Inhibitors Through the Windows of EMPA-REG and CANVAS Trials: A Review
EMPA-REG OUTCOME and CANVAS trials were designed to study the cardiovascular safety of empagliflozin and canagliflozin, respectively. Both studies were sufficiently powered to study the non-inferiority for cardiovascular (CV) outcomes in patients with type 2 diabetes mellitus (DM) and showed superiority for major adverse cardiovascular events and composite renal outcomes independent of glycemic...
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In most cases atherosclerosis is the underlying cause of vascular diseases, including heart disease and stroke. It is believed that endothelial injury is the earliest change in the artery wall and that this precedes the formation of lesions of atherosclerosis. Recent developments in the field of atherosclerosis have led to a renewed interest in the recognition of the parameter of time in the at...
متن کاملthe effect of classroom observation on eflteachers skills ans students outcomes
abstract the following study, in the first place, attempted to examine the effect of less experienced teachers participation in experienced teachers classes on their own skills and teaching methodology, in the second place, attempted to find out the role of teachers training in students achievements. for this purpose, 21 efl teachers were selected according to available sampling in kish l...
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ژورنال
عنوان ژورنال: Expert Opinion on Pharmacotherapy
سال: 2017
ISSN: 1465-6566,1744-7666
DOI: 10.1080/14656566.2017.1418855